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N'ime afọ ndị na-adịbeghị anya, extracellular vesicles (EVs) adọtala uche ndị mmadụ dị ka ihe nwere ike ịgwọ ọrịa;Otú ọ dị, a kọpụtabeghị mmetụta ọgwụgwọ EVs na endometriosis.Endometriosis bụ ọrịa gynecological na-adịghị njọ nke na-emetụta 10-15% nke ụmụ nwanyị na-amụ nwa, na-akpata mgbaàmà dị iche iche, na-ebute ọdịda nke ndụ ndụ na nnukwu ibu ọrụ ọha na eze.
Okwu Mmalite
410Na Julaị 20, 2021, ndị otu nyocha nke Prọfesọ Wang Guoyun sitere na Hospitallọ Ọgwụ Qilu nke Mahadum Shandong bipụtara akwụkwọ nyocha nke akpọrọ “M1 Macrophage-Derived Nanovesicles Repolarize M2 Macrophages for Inhibiting the Development of Endometriosis” na Frontiers na immunology, nke tụlere mwepụta nke M1 macrophages.Ohere nke nanovesicles (NVs) na ọgwụgwọ nke endometriosis.
Isiokwu a na-eji usoro extrusion na-aga n'ihu iji kwadebe M1NVs, ma na-eji usoro omenala na-amụ mgbanwe na angiogenesis, Mbugharị, mbuso agha na ihe ndị ọzọ na-egosi eutopic endometrial stromal cell (EM-ESCs) site na ndị ọrịa nwere endometriosis.N'otu oge ahụ, e guzobere ụdị òké nke endometriosis, na ụmụ oke na-eji PBS, MONVs ma ọ bụ M1NV, n'otu n'otu, iji nyochaa irè na nchekwa nke M1NV na ọgwụgwọ nke endometriosis.
Nsonaazụ gosiri na in vitro M1NV nwere ike igbochi mbugharị na mbuso agha nke EM-ESC ozugbo ma ọ bụ na-apụtaghị ìhè, ma gbochie angiogenesis.N'ụdị òké, M1NV na-egbochi omume nke endometriosis site na M2 macrophage reprogramming na-emebighị akụkụ ahụ.Ọ na-egosi na M1NV nwere ike igbochi ọnọdụ nke endometriosis ozugbo, ma enwere ike igbochi ya site na ịmegharị ụdị macrophages M2 na ụdị M1.Ya mere, iji M1NV nwere ike ịbụ usoro ọhụrụ maka ọgwụgwọ endometriosis.
Enyemaka mbụ
411N'ime ọmụmụ ihe ahụ, n'ihi na a na-akwado M1NV site na ịpịa M1 macrophages na-aga n'ihu, isiokwu ahụ jiri qRT-PCR chọpụta ihe ndị na-eme ka ọ bụrụ ihe na-eme ka ọ bụrụ ihe na-eme ka ọ bụrụ ihe na-eme ka ọ bụrụ M1 macrophage iNOS, TNF-a na IL-6 mRNA na M1NV na M1 macrophages.Ọnụọgụ mgbanwe mgbanwe.Nsonaazụ gosiri na M1NV nwere ihe pro-inflammatory mRNA na M1 macrophage markers, na-egosi na M1NV nwere ike ijigide njirimara arụ ọrụ nke mkpụrụ ndụ M1 nke ọma.Usoro nyocha a na-eji QuickEasy Cell Direct RT-qPCR Kit-SYBR Green I nke Foregene
Cell Direct RT-qPCR Kitnkọwa
412
Ọnọdụ ngwa:
 
1. Usoro nchịkwa na nyocha okwu, nkwenye nke mkpụrụ ndụ ihe nketa ma ọ bụ mmetụta nnyonye anya, nyocha ọgwụ, wdg;
2. Nchọpụta mkpụrụ ndụ ihe nketa nke mkpụrụ ndụ ndị siri ike na-akụ dị ka mkpụrụ ndụ isi, sel stem, na mkpụrụ ndụ akwara;
3. Nchọpụta nke mRNA na ihe atụ dị ka exosomes na nanovesicles.
Atụmatụ:
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Oge nzipu: Sep-03-2021