Isi mmalite: WuXi AppTec

N'afọ ndị na-adịbeghị anya, ngalaba ọgwụgwọ RNA egosila usoro mgbawa-N'ime afọ 5 gara aga naanị, FDA akwadoro ọgwụgwọ RNA 11, na ọnụọgụ a karịrị nchikota nke usoro ọgwụgwọ RNA akwadoro na mbụ!E jiri ya tụnyere usoro ọgwụgwọ ọdịnala, ọgwụgwọ RNA nwere ike ịmepụta usoro ọgwụgwọ ezubere iche ngwa ngwa nwere oke ọganiihu dị elu ma ọ bụrụhaala na amaara usoro mkpụrụ ndụ ihe mgbaru ọsọ.N'aka nke ọzọ, ọtụtụ ọgwụgwọ RNA ka dị naanị iji gwọọ ọrịa ndị na-adịghị ahụkebe, na mmepe nke usoro ọgwụgwọ ndị dị otú ahụ ka na-eche ọtụtụ ihe ịma aka ihu n'ihe gbasara ogologo oge ọgwụgwọ, nchekwa na nnyefe.N'isiokwu taa, naOtu ọdịnaya nke WuXi AppTec ga-enyocha ọganihu na ngalaba ọgwụgwọ RNA n'afọ gara aga, ma na-atụ anya ọdịnihu nke ubi a na-apụta na ndị na-agụ akwụkwọ.

▲ Usoro ọgwụgwọ RNA ma ọ bụ ọgwụ mgbochi 11 ka FDA kwadoro n'ime afọ 5 gara aga

Site na ọrịa ndị na-adịghị ahụkebe na ọrịa nkịtị, ọtụtụ okooko osisi na-eto

Na ntiwapụ nke okpueze ọhụrụ ahụ, a mụrụ ọgwụ mgbochi mRNA n'enweghị ebe ọ bụla wee nweta nlebara anya zuru oke site na ụlọ ọrụ ahụ.Mgbeọganihu na mmepe nke ọgwụ mgbochi ọrịa na-efe efe, nnukwu ihe ịma aka ọzọ chere teknụzụ mRNA ihu bụ ịgbasa ngwa ngwa maka ọgwụgwọ na mgbochi nke ọrịa ndị ọzọ.
N'etiti ha,Ọgwụ mgbochi ọrịa kansa n'otu n'otu bụ mpaghara ngwa dị mkpa nke teknụzụ mRNA, na anyị ahụwokwa ezigbo nsonaazụ ụlọ ọgwụ nke ọtụtụ ọgwụ mgbochi ọrịa kansa n'afọ a.Naanị ọnwa a, ọgwụ mgbochi ọrịa cancer ahaziri iche nke Moderna na Merck mebere, yana PD-1 inhibitor Keytruda,belatara ihe ize ndụnke nlọghachite ma ọ bụ ọnwụ na ndị ọrịa nwere ogbo III na IV melanoma mgbe nchịkọta tumor zuru oke site na 44% (ma e jiri ya tụnyere Keytruda monotherapy).Mwepụta akwụkwọ akụkọ ahụ rụtụrụ aka na nke a bụ nke mbụ ọgwụ mgbochi ọrịa kansa mRNA gosipụtara ịdị irè na ọgwụgwọ nke melanoma na nnwale ụlọ ọgwụ na-enweghị usoro, nke bụ ihe omume dị ịrịba ama na mmepe nke ọgwụ mgbochi ọrịa kansa mRNA.
Na mgbakwunye, ọgwụ mgbochi mRNA nwekwara ike ịkwalite mmetụta ọgwụgwọ nke ọgwụgwọ cell.Dịka ọmụmaatụ, ọmụmụ nke BioNTech mere ka ọ pụta ìhè na ọ bụrụ na ebu ụzọ nye ndị ọrịa obere ọgwụ CLDN6 ezubere iche maka ọgwụgwọ CAR-T.BNT211, wee gbanye ya na ọgwụ mgbochi mRNA nke na-edobe CLDN6, ha nwere ike kpalite mkpụrụ ndụ CAR-T na vivo site n'igosipụta CLDN6 n'elu sel ndị na-eweta antigen.Amplification, si otú ahụ na-akwalite mmetụta anticancer.Nsonaazụ mbụ gosiri na 4 n'ime ndị ọrịa 5 nwetara ọgwụgwọ nchikota nwetara nzaghachi nke akụkụ, ma ọ bụ 80%.

Na mgbakwunye na ọgwụgwọ mRNA, ọgwụgwọ oligonucleotide na ọgwụgwọ RNAi enwetawokwa ezigbo nsonaazụ n'ịgbasa oke ọrịa.N'ịgwọ ọrịa ịba ọcha n'anya B na-adịghị ala ala, ihe fọrọ nke nta ka ọ bụrụ pasent 30 nke ndị ọrịa enweghị ike ịchọpụta ịba ọcha n'anya B surface antigen na nje ịba ọcha n'anya B DNA na vivo mgbe ha jiri ọgwụ antisense oligonucleotide.bepirovirsen jikọrọ aka nke GSK na Ionis mepụtaramaka izu iri abụọ na anọ.N'ime ụfọdụ ndị ọrịa, ọbụlagodi izu 24 ka ịkwụsị ọgwụgwọ, akara ndị a nke ịba ọcha n'anya B ka achọpụtaghị n'ime ahụ.
N'otu aka ahụ, ọgwụgwọ RNAiVIR-2218 jikọtara ya na Vir Biotechnology na Alnylam jikọtara yana interferon α, na na nkeji 2 ule ụlọ ọgwụ, ihe dị ka 30% nke ndị ọrịa ịba ọcha n'anya B na-adịghị ala ala achọpụtakwaghị ịba ọcha n'anya B surface antigen (HBsAg).Na mgbakwunye, ndị ọrịa a mepụtara ọgwụ mgbochi megide protein ịba ọcha n'anya B, na-egosi nzaghachi usoro ahụ ji alụso ọrịa ọgụ dị mma.N'ịchịkọta nsonaazụ ndị a ọnụ, ụlọ ọrụ na-arụtụ aka na ọgwụgwọ RNA nwere ike ịbụ isi ihe na-agwọ ọrịa ịba ọcha n'anya B.
Nke a nwere ike ịbụ mmalite ọgwụgwọ RNA maka ọrịa nkịtị.Dabere na pipeline R&D nke Alnylam, ọ na-etolitekwa usoro ọgwụgwọ RNAi maka ọgwụgwọ ọbara mgbali elu, ọrịa Alzheimer, na steatohepatitis na-abụghị mmanya na-aba n'anya, na ọdịnihu kwesịrị ịtụ anya.

Na-agbaji n'ikuku nke nnyefe ọgwụgwọ RNA

Nnyefe ọgwụgwọ RNA bụ otu n'ime ihe mgbochi na-egbochi ngwa ya.Ndị ọkà mmụta sayensị na-emepụtakwa teknụzụ dị iche iche iji nyefee ọgwụgwọ RNA kpọmkwem na akụkụ ahụ na anụ ahụ na-abụghị imeju.
Otu n'ime ụzọ enwere ike bụ iji ụmụ irighiri ihe nwere anụ ahụ 'jikọta' RNA ọgwụgwọ.Dịka ọmụmaatụ, Avidity Biosciences kwupụtara n'oge na-adịbeghị anya na ikpo okwu teknụzụ ya nwere ike jikọta ọgwụ mgbochi monoclonal na oligonucleotides.Jikọọ siRNA nke ọma.ezigara akwara skeletal.Mwepụta akwụkwọ akụkọ ahụ rụtụrụ aka na nke a bụ nke mbụ enwere ike ịchebe siRNA nke ọma wee nyefee anụ ahụ mmadụ, nke bụ nnukwu ọganiihu na ngalaba ọgwụgwọ RNA.

Isi iyi: 123RF

Na mgbakwunye na teknụzụ njikọ mgbochi mmadụ, ọtụtụ ụlọ ọrụ na-emepụta lipid nanoparticles (LNP) na-ebulikwa ụdị ndị ahụ.Ọmụmaatụ, ReCode Therapeuticna-eji teknụzụ Selective Organ Targeting LNP (SORT) pụrụ iche na-ebuga ụdị ọgwụgwọ RNA dị iche iche na ngụgụ, splin, imeju na akụkụ ahụ ndị ọzọ.N'afọ a, ụlọ ọrụ ahụ kwupụtara mmecha nke US $ 200 nde Series B nke ego, yana ngalaba isi ụlọ ọrụ nke Pfizer, Bayer, Amgen, Sanofi na nnukwu ụlọ ọrụ ọgwụ ndị ọzọ na-ekere òkè na ntinye ego.Kernal Biologics , nke natara $ 25 nde na usoro ego nke afọ a, na-emepekwa LNP nke na-adịghị agbakọba n'ime imeju, ma nwere ike ịnapụta mRNA na sel ndị dị ka ụbụrụ ma ọ bụ ụbụrụ kpọmkwem.
Orbital Therapeutics , nke debuted afọ a, na-ewerekwa nnyefe nke RNA ọgwụgwọ dị ka isi mmepe ntụziaka.Site na ijikọ teknụzụ RNA na usoro nnyefe, ụlọ ọrụ ahụ na-atụ anya iwulite teknụzụ teknụzụ RNA pụrụ iche nke nwere ike ịgbatị nnọgidesi ike na ọkara ndụ nke ọgwụgwọ RNA ọhụrụ ma nyefee ha n'ụdị sel na anụ ahụ dị iche iche.

Ụdị ọgwụgwọ RNA ọhụrụ na-apụta n'oge akụkọ ihe mere eme

N'ihe dị ka ọnwa Disemba 21 nke afọ a, na ngalaba ọgwụgwọ RNA, enweela ihe omume ego mbụ 31 (lee usoro na njedebe nke isiokwu maka nkọwa), metụtara ụlọ ọrụ 30 na-egbu egbu (otu ụlọ ọrụ enwetala ego ugboro abụọ), yana ngụkọta ego ruru ijeri dollar 1.74.Nyocha nke ụlọ ọrụ ndị a na-egosi na ndị na-etinye ego na-enwekwu nchekwube banyere ụlọ ọrụ ndị ahụ na-akpachapụ anya nke a na-atụ anya na ha ga-edozi ọtụtụ ihe ịma aka nke ọgwụgwọ RNA, iji ghọta nke ọma ikike ọgwụgwọ RNA na-erite uru na ọtụtụ ndị ọrịa.
Ma enwere ụlọ ọrụ na-abata na-emepụta ụdị ọgwụgwọ RNA ọhụrụ kpamkpam.N'adịghị ka oligonucleotides ọdịnala, RNAi ma ọ bụ mRNA, ụdị mkpụrụ ndụ RNA ọhụrụ nke ụlọ ọrụ ndị a mepụtara na-atụ anya na ha ga-esi na njedebe nke usoro ọgwụgwọ dị adị.
RNA okirikiri bụ otu n'ime ebe na-ekpo ọkụ na ụlọ ọrụ.E jiri ya tụnyere mRNA linear, teknụzụ okirikiri RNA nke ụlọ ọrụ na-akpachapụ anya nke a na-akpọ Orna Therapeutics nwere ike ịzenarị ka a mata ya site na usoro ahụ ji alụso ọrịa ọgụ na exonucleases, nke na-abụghị nanị na-ebelata immunogenicity, ma nweekwa nkwụsi ike dị elu.Na mgbakwunye, ma e jiri ya tụnyere RNA linear, nchikota nke RNA okirikiri dị ntakịrị, yana RNA okirikiri nwere ike iji otu LNP buru ibu, na-eme ka usoro ọgwụgwọ RNA dịkwuo mma.Atụmatụ ndị a nwere ike inye aka melite ike na ịdịte aka nke ọgwụgwọ RNA.
N'afọ a, ụlọ ọrụ ahụ mezuru usoro ego nke ijeri US $ 221, ma rutekwa nyocha nankwado mmepe na Merck ruru ijeri US $ 3.5.Na mgbakwunye, Orna na-ejikwa RNA okirikiri na-emepụta ọgwụgwọ CAR-T ozugbo na anụmanụ, na-emecha ihe akaebe nkeechiche.
Na mgbakwunye na RNA okirikiri, teknụzụ mRNA (samRNAs) na-eme ka onwe ya nwee mmasị na ndị ọchụnta ego.Teknụzụ a gbadoro ụkwụ na usoro nkwalite onwe nke nje RNA, nke nwere ike ime ka mmegharị nke usoro samRNA dị na cytoplasm, na-agbatịkwu okwu kinetics nke ọgwụgwọ mRNA, si otú ahụ belata oge nchịkwa.Tụnyere mRNA linear ọdịnala, samRNA nwere ike idowe ọkwa okwu protein yiri nke ahụ na ihe dị ka okpukpu iri dị ala.N'afọ a, RNAimmune, nke na-elekwasị anya na mmepe nke ubi a, natara US $ 27 nde na ego Series A.
Teknụzụ tRNA dịkwa mma ịtụ anya ya.Usoro ọgwụgwọ dabere na tRNA nwere ike "leghara" codon nkwụsị na-ezighi ezi mgbe cell na-emepụta protein, nke mere na a na-emepụta protein zuru oke.N'ihi na ụdị codons nkwụsị dị ntakịrị karịa ọrịa ndị metụtara ya, ọgwụgwọ tRNA nwere ike ịmepụta otu ọgwụgwọ nke nwere ike ịgwọ ọtụtụ ọrịa.N'afọ a, hC Bioscience , nke na-elekwasị anya na ọgwụgwọ tRNA, ewepụtala ngụkọta nke US $ 40 nde na ego Series A.

Epilogu

Dị ka usoro ọgwụgwọ na-apụta, ọgwụgwọ RNA enwetawo mmepe ngwa ngwa n'afọ ndị na-adịbeghị anya, a kwadoro ọtụtụ ọgwụgwọ.Site na mmepe kachasị ọhụrụ na ụlọ ọrụ ahụ, a pụrụ ịhụ na ọgwụgwọ RNA na-egbu egbu na-agbasawanye ụdị ọrịa nke usoro ọgwụgwọ ndị dị otú ahụ nwere ike ịgwọ, na-emeri ihe mgbochi dị iche iche na nnyefe ezubere iche, na ịmepụta mkpụrụ ndụ RNA ọhụrụ iji merie njedebe nke ọgwụgwọ ndị dị ugbu a n'ihe gbasara ịdị irè na ịdịte aka.otutu ihe ịma aka.N'ime oge ọhụrụ a nke ọgwụgwọ RNA, ụlọ ọrụ ndị a na-akpachapụ anya nwere ike bụrụ ebe ụlọ ọrụ na-elekwasị anya n'ime afọ ole na ole sochirinụ.

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